GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

Dong Deng, Nieng Yan

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental process for metabolism, growth, and homeostasis. Three families of secondary glucose transporters have been identified in human, including the major facilitator superfamily glucose facilitators GLUTs, the sodium-driven glucose symporters SGLTs, and the recently identified SWEETs. Structures of representative members or their prokaryotic homologs of all three families were obtained. This review focuses on the recent advances in the structural elucidation of the glucose transporters and the mechanistic insights derived from these structures, including the molecular basis for substrate recognition, alternating access, and stoichiometric coupling of co-transport.

Original languageEnglish (US)
Pages (from-to)546-558
Number of pages13
JournalProtein Science
Volume25
Issue number3
DOIs
StatePublished - Mar 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Keywords

  • GLUT
  • SGLT
  • SWEET
  • alternating access
  • glucose transporter
  • structural biology

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