Globularity and protein function

Research output: Contribution to journalArticlepeer-review


The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular-spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside. The near-universality of these features of protein structures sharpens our focus on some apparent exceptions. Consideration of the structure/function link in some of the exceptional cases provides some insights into our views of protein function.

Original languageEnglish (US)
Pages (from-to)87-88
Number of pages2
JournalJournal of Biomolecular Structure and Dynamics
Issue numberSUPPL. 1
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology


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