TY - JOUR
T1 - Getting to the end
T2 - Telomerase access in yeast and humans
AU - Vega, Leticia R.
AU - Mateyak, Maria K.
AU - Zakian, Virginia A.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.
AB - In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.
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U2 - 10.1038/nrm1256
DO - 10.1038/nrm1256
M3 - Review article
C2 - 14685173
AN - SCOPUS:0345169051
VL - 4
SP - 948
EP - 959
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 12
ER -