Getting to the end: Telomerase access in yeast and humans

Leticia R. Vega; Maria K. Mateyak; Virginia A. Zakian

doi:10.1038/nrm1256

Getting to the end: Telomerase access in yeast and humans

Leticia R. Vega, Maria K. Mateyak, Virginia A. Zakian

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.

Original language	English (US)
Pages (from-to)	948-959
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1038/nrm1256
State	Published - Dec 2003

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nrm1256

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title = "Getting to the end: Telomerase access in yeast and humans",

abstract = "In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.",

author = "Vega, {Leticia R.} and Mateyak, {Maria K.} and Zakian, {Virginia A.}",

note = "Funding Information: We thank T. Fisher and M. Sabourin for critical reading of the manuscript, S. Schnakenberg for help with the figures and B. Lenzmeier and J. Bessler for thoughtful discussions. Work in the Zakian lab is supported by grants from the National Institutes of Health (NIH). M.K.M. is supported by the Damon Runyon Cancer Research Foundation. L.R.V. was funded in part by the Helen Hay Whitney Foundation and by the NIH.",

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AU - Mateyak, Maria K.

AU - Zakian, Virginia A.

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PY - 2003/12

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N2 - In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.

AB - In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.

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Getting to the end: Telomerase access in yeast and humans

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