Getting it done at the ends: Pif1 family DNA helicases and telomeres

Carly L. Geronimo, Virginia A. Zakian

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

It is widely appreciated that the ends of linear DNA molecules cannot be fully replicated by the conventional replication apparatus. Less well known is that semi-conservative replication of telomeric DNA also presents problems for DNA replication. These problems likely arise from the atypical chromatin structure of telomeres, the GC-richness of telomeric DNA that makes it prone to forming DNA secondary structures, and from RNA-DNA hybrids, formed by transcripts of one or both DNA strands. Given the different aspects of telomeres that complicate their replication, it is not surprising that multiple DNA helicases promote replication of telomeric DNA. This review focuses on one such class of DNA helicases, the Pif1 family of 5′–3′ DNA helicases. In budding and fission yeasts, Pif1 family helicases impact both telomerase-mediated and semi-conservative replication of telomeric DNA as well as recombination-mediated telomere lengthening.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalDNA Repair
Volume44
DOIs
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • ALT
  • Break induced replication
  • DNA replication
  • Helicase
  • Pif1
  • TERRA
  • Telomerase
  • Telomere

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