Getting genetic ancestry right for science and society

Anna C.F. Lewis, Santiago J. Molina, Paul S. Appelbaum, Bege Dauda, Anna Di Rienzo, Agustin Fuentes, Stephanie M. Fullerton, Nanibaa A. Garrison, Nayanika Ghosh, Evelynn M. Hammonds, David S. Jones, Eimear E. Kenny, Peter Kraft, Sandra S.J. Lee, Madelyn Mauro, John Novembre, Aaron Panofsky, Mashaal Sohail, Benjamin M. Neale, Danielle S. Allen

    Research output: Contribution to journalArticlepeer-review

    77 Scopus citations

    Abstract

    Glaring health disparities have reinvigorated debate about the relevance of race to health, including how race should and should not be used as a variable in research and biomedicine (1). After a long history of race being treated as a biological variable, there is now broad agreement that racial classifications are a product of historically contingent social, economic, and political processes. Many institutions have thus been reexamining their use of race and racism and stating intentions about how race should be used going forward. One common proposal is to use genetic concepts-in particular, genetic ancestry and population categories-as a replacement for race (2). However, the use of ancestry categories has technical limitations, fails to adequately capture human genetic diversity and demographic history, and risks retaining one of the most problematic aspects of race-an essentialist link to biology-by allowing genetic ancestry categories to stand in its place.

    Original languageEnglish (US)
    Pages (from-to)250-252
    Number of pages3
    JournalScience
    Volume376
    Issue number6590
    DOIs
    StatePublished - Apr 15 2022

    All Science Journal Classification (ASJC) codes

    • General

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