Geometric control of tissue morphogenesis

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Morphogenesis is the dynamic and regulated change in tissue form that leads to creation of the body plan and development of mature organs. Research over the past several decades has uncovered a multitude of genetic factors required for morphogenesis in animals. The behaviors of individual cells within a developing tissue are determined by combining these genetic signals with information from the surrounding microenvironment. At any point in time, the local microenvironment is influenced by macroscale tissue geometry, which sculpts long range signals by affecting gradients of morphogens and mechanical stresses. The geometry of a tissue thus acts as both a template and instructive cue for further morphogenesis.

Original languageEnglish (US)
Pages (from-to)903-910
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1793
Issue number5
DOIs
StatePublished - May 2009

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • Emergence
  • Mechanotransduction
  • Multicellular form
  • Pattern formation

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