@article{1c469ba639254f5296e57c9c8e7e0c74,
title = "Geographic clustering of polygenic scores at different stages of the life course",
abstract = "We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual's educational attainment net of that person's polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.",
keywords = "Genetics, Geography, Polygenic scores",
author = "Domingue, {Benjamin W.} and Rehkopf, {David H.} and Dalton Conley and Boardman, {Jason D.}",
note = "Funding Information: {\textcopyright} 2018 Russell Sage Foundation. Domingue, Benjamin W., David H. Rehkopf, Dalton Conley, and Jason D. Board - man. 2018. “Geographic Clustering of Polygenic Scores at Different Stages of the Life Course.” RSF: The Russell Sage Foundation Journal of the Social Sciences 4(4): 137–49. DOI: 10.7758/RSF.2018.4.4.08. The Health and Retirement Study is sponsored by the National Institute on Aging (grant number NIA U01AG009740) and is conducted by the University of Michigan. Research supported in part by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD066613: University of Colorado Population Center) and R21 HD078031 and the National Institute of Aging (K01AG047280). This research was facilitated by the Social Science Genetic Association Consortium. Direct correspondence to: Ben W. Domingue at bdom-ingue@stanford.edu, 520 Galvez Mall, Stanford, CA 94305; David H. Rehkopf at drehkopf@stanford.edu, 1070 Arastradero Rd., Room 305, Palo Alto, CA 94304; Dalton Conley at dconley@princeton.edu, 157 Wallace Hall, Princeton, NJ 08544; and Jason D. Boardman at boardman@colorado.edu, 1440 15th St., Boulder, CO 80309.",
year = "2018",
month = apr,
doi = "10.7758/rsf.2018.4.4.08",
language = "English (US)",
volume = "4",
pages = "137--149",
journal = "RSF",
issn = "2377-8253",
publisher = "Russell Sage Foundation",
number = "4",
}