Genomic regulatory networks and animal development

Angelike Stathopoulos, Michael Levine

Research output: Contribution to journalReview article

184 Scopus citations

Abstract

The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of genomic regulatory networks. These networks provide a direct visualization of the functional interconnections among the regulatory genes and signaling components leading to cell-specific patterns of gene activity. Complex developmental processes are thereby illuminated in ways not revealed by the conventional analysis of individual genes. In this review, we describe emerging networks in several different model systems, and compare them with the gene regulatory network that controls dorsoventral patterning of the Drosophila embryo.

Original languageEnglish (US)
Pages (from-to)449-462
Number of pages14
JournalDevelopmental cell
Volume9
Issue number4
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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