Genomic regulatory networks and animal development

Angelike Stathopoulos, Michael Levine

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of genomic regulatory networks. These networks provide a direct visualization of the functional interconnections among the regulatory genes and signaling components leading to cell-specific patterns of gene activity. Complex developmental processes are thereby illuminated in ways not revealed by the conventional analysis of individual genes. In this review, we describe emerging networks in several different model systems, and compare them with the gene regulatory network that controls dorsoventral patterning of the Drosophila embryo.

Original languageEnglish (US)
Pages (from-to)449-462
Number of pages14
JournalDevelopmental cell
Issue number4
StatePublished - Oct 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


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