Genomic Analysis of Foxp3 Function in Regulatory T Cells

Gabriel A. Dolsten, Yuri Pritykin

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

Original languageEnglish (US)
Pages (from-to)880-887
Number of pages8
JournalJournal of Immunology
Volume210
Issue number7
DOIs
StatePublished - Apr 1 2023

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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