Genomic Analysis of Foxp3 Function in Regulatory T Cells

Gabriel A. Dolsten; Yuri Pritykin

doi:10.4049/jimmunol.2200864

Genomic Analysis of Foxp3 Function in Regulatory T Cells

Gabriel A. Dolsten, Yuri Pritykin

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

Original language	English (US)
Pages (from-to)	880-887
Number of pages	8
Journal	Journal of Immunology
Volume	210
Issue number	7
DOIs	https://doi.org/10.4049/jimmunol.2200864
State	Published - Apr 1 2023

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.4049/jimmunol.2200864

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abstract = "Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.",

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AB - Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

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Genomic Analysis of Foxp3 Function in Regulatory T Cells

Abstract

All Science Journal Classification (ASJC) codes

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