Genome sequence of the virulent model herpes simplex virus 1 strain McKrae demonstrates the presence of at least two widely used variant strains

Daniel W. Renner; Lance Parsons; Jacob T. Shreve; Esteban A. Engel; Chad V. Kuny; Lynn Enquist; Donna Neumann; Colleen Mangold; Moriah L. Szpara

doi:10.1128/MRA.01146-19

Genome sequence of the virulent model herpes simplex virus 1 strain McKrae demonstrates the presence of at least two widely used variant strains

Daniel W. Renner
, Lance Parsons
, Jacob T. Shreve
, Esteban A. Engel
, Chad V. Kuny
, Lynn Enquist
, Donna Neumann
, Colleen Mangold
, Moriah L. Szpara

Princeton Neuroscience Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 strain McKrae from the laboratory of James M. Hill to better understand the genetic differences between isolates.

Original language	English (US)
Article number	e01146-19
Journal	Microbiology Resource Announcements
Volume	10
Issue number	12
DOIs	https://doi.org/10.1128/MRA.01146-19
State	Published - Mar 25 2021

All Science Journal Classification (ASJC) codes

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

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10.1128/MRA.01146-19

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Renner, D. W., Parsons, L., Shreve, J. T., Engel, E. A., Kuny, C. V., Enquist, L., Neumann, D., Mangold, C., & Szpara, M. L. (2021). Genome sequence of the virulent model herpes simplex virus 1 strain McKrae demonstrates the presence of at least two widely used variant strains. Microbiology Resource Announcements, 10(12), Article e01146-19. https://doi.org/10.1128/MRA.01146-19

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abstract = "Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 strain McKrae from the laboratory of James M. Hill to better understand the genetic differences between isolates.",

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AU - Renner, Daniel W.

AU - Parsons, Lance

AU - Shreve, Jacob T.

AU - Engel, Esteban A.

AU - Kuny, Chad V.

AU - Enquist, Lynn

AU - Neumann, Donna

AU - Mangold, Colleen

AU - Szpara, Moriah L.

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AB - Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 strain McKrae from the laboratory of James M. Hill to better understand the genetic differences between isolates.

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ER -

Genome sequence of the virulent model herpes simplex virus 1 strain McKrae demonstrates the presence of at least two widely used variant strains

Abstract

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