Genome mining for lasso peptides: past, present, and future

Wai Ling Cheung-Lee, A. James Link

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven approaches, now, the vast majority of lasso peptide discovery is driven by genome-mining approaches. This paper starts with a historical overview of the first genome-mining approaches for lasso peptide discovery, and then covers new tools that have emerged. Several examples of novel lasso peptides that have been discovered via genome mining are presented as are examples of new enzymes found associated with lasso peptide gene clusters. Finally, this paper concludes with future directions and unsolved challenges in lasso peptide genome mining.

Original languageEnglish (US)
Pages (from-to)1371-1379
Number of pages9
JournalJournal of Industrial Microbiology and Biotechnology
Issue number9-10
StatePublished - Oct 1 2019

All Science Journal Classification (ASJC) codes

  • General Medicine


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