Genetic differential sensitivity to social environments: Implications for research

Colter Mitchell, Sara McLanahan, Jeanne Brooks-Gunn, Irwin Garfinkel, John Hobcraft, Daniel Notterman

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Researchers have proposed a genetic differential sensitivity to social environmental (GDSE) model positing that individuals with certain genetic makeups are more sensitive to favorable and unfavorable environmental influences than those without these genetic makeups. We discuss several issues facing researchers who want to use GDSE to examine health: (1) the need for greater theorizing about the social environment to properly understand the size and direction of environmental influences; (2) the potential for combining multiple genetic markers to measure an individual's genetic sensitivity to environmental influence; (3) how this model and exogenous shocks deal with gene-environment correlations; (4) implications of this model for public health and prevention; and (5) how life course and developmental theories may be used to inform GDSE research.

Original languageEnglish (US)
Pages (from-to)S102-S110
JournalAmerican Journal of Public Health
Issue numberSUPPL.1
StatePublished - Oct 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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