Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin

U. S. Eggert, N. Ruiz, B. V. Falcone, A. A. Branstrom, R. C. Goldman, T. J. Silhavy, D. Kahne

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Small molecules that affect specific protein functions can be valuable tools for dissecting complex cellular processes. Peptidoglycan synthesis and degradation is a process in bacteria that involves multiple enzymes under strict temporal and spatial regulation. We used a set of small molecules that inhibit the transglycosylation step of peptidoglycan synthesis to discover genes that help to regulate this process. We identified a gene responsible for the susceptibility of Escherichia coli cells to killing by glycolipid derivatives of vancomycin, thus establishing a genetic basis for activity differences between these compounds and vancomycin.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalScience
Volume294
Issue number5541
DOIs
StatePublished - Oct 12 2001

All Science Journal Classification (ASJC) codes

  • General

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    Eggert, U. S., Ruiz, N., Falcone, B. V., Branstrom, A. A., Goldman, R. C., Silhavy, T. J., & Kahne, D. (2001). Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin. Science, 294(5541), 361-364. https://doi.org/10.1126/science.1063611