Genetic analysis of the ompB locus in Escherichia coli K-12

Michael N. Hall; Thomas J. Silhavy

doi:10.1016/0022-2836(81)90218-7

Genetic analysis of the ompB locus in Escherichia coli K-12

Michael N. Hall
, Thomas J. Silhavy

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Fine-structure mapping and complementation analysis of the ompB locus indicate that this locus is comprised of two genes, envZ and ompR. These genes are ordered on the chromosome as follows: aroB-envZ-ompR-asd. A model is proposed for the ompB-mediated regulation of the major outer membrane porin genes, ompF and ompC. According to this model, the ompR gene product is a bifunctional regulatory protein. The envZ gene product is an envelope protein that senses the cell's external environment.

Original language	English (US)
Pages (from-to)	1-15
Number of pages	15
Journal	Journal of Molecular Biology
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/0022-2836(81)90218-7
State	Published - Sep 5 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Structural Biology

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10.1016/0022-2836(81)90218-7

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title = "Genetic analysis of the ompB locus in Escherichia coli K-12",

abstract = "Fine-structure mapping and complementation analysis of the ompB locus indicate that this locus is comprised of two genes, envZ and ompR. These genes are ordered on the chromosome as follows: aroB-envZ-ompR-asd. A model is proposed for the ompB-mediated regulation of the major outer membrane porin genes, ompF and ompC. According to this model, the ompR gene product is a bifunctional regulatory protein. The envZ gene product is an envelope protein that senses the cell's external environment.",

author = "Hall, \{Michael N.\} and Silhavy, \{Thomas J.\}",

note = "Funding Information: We thank D. Jackson for assiduousa ssistancew ith fl-galactosidasea ssays,a nd P. Fritz and S. Lucas for their help in typing the manuscript.T his research was sponsored by the National Cancer Institute under contract no. NOl-CO-75380 wit{\textquoteright}h Litton Bionetics, Inc.",

year = "1981",

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doi = "10.1016/0022-2836(81)90218-7",

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T1 - Genetic analysis of the ompB locus in Escherichia coli K-12

AU - Hall, Michael N.

AU - Silhavy, Thomas J.

N1 - Funding Information: We thank D. Jackson for assiduousa ssistancew ith fl-galactosidasea ssays,a nd P. Fritz and S. Lucas for their help in typing the manuscript.T his research was sponsored by the National Cancer Institute under contract no. NOl-CO-75380 wit’h Litton Bionetics, Inc.

PY - 1981/9/5

Y1 - 1981/9/5

N2 - Fine-structure mapping and complementation analysis of the ompB locus indicate that this locus is comprised of two genes, envZ and ompR. These genes are ordered on the chromosome as follows: aroB-envZ-ompR-asd. A model is proposed for the ompB-mediated regulation of the major outer membrane porin genes, ompF and ompC. According to this model, the ompR gene product is a bifunctional regulatory protein. The envZ gene product is an envelope protein that senses the cell's external environment.

AB - Fine-structure mapping and complementation analysis of the ompB locus indicate that this locus is comprised of two genes, envZ and ompR. These genes are ordered on the chromosome as follows: aroB-envZ-ompR-asd. A model is proposed for the ompB-mediated regulation of the major outer membrane porin genes, ompF and ompC. According to this model, the ompR gene product is a bifunctional regulatory protein. The envZ gene product is an envelope protein that senses the cell's external environment.

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Genetic analysis of the ompB locus in Escherichia coli K-12

Abstract

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