Genetic analysis of the ompB locus in Escherichia coli K-12

Michael N. Hall, Thomas J. Silhavy

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


Fine-structure mapping and complementation analysis of the ompB locus indicate that this locus is comprised of two genes, envZ and ompR. These genes are ordered on the chromosome as follows: aroB-envZ-ompR-asd. A model is proposed for the ompB-mediated regulation of the major outer membrane porin genes, ompF and ompC. According to this model, the ompR gene product is a bifunctional regulatory protein. The envZ gene product is an envelope protein that senses the cell's external environment.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalJournal of Molecular Biology
Issue number1
StatePublished - Sep 5 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology


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