Generic Theoretical Models to Predict Division Patterns of Cleaving Embryos

Anaëlle Pierre, Jérémy Sallé, Martin Wühr, Nicolas Minc

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Life for all animals starts with a precise 3D choreography of reductive divisions of the fertilized egg, known as cleavage patterns. These patterns exhibit conserved geometrical features and striking interspecies invariance within certain animal classes. To identify the generic rules that may govern these morphogenetic events, we developed a 3D-modeling framework that iteratively infers blastomere division positions and orientations, and consequent multicellular arrangements. From a minimal set of parameters, our model predicts detailed features of cleavage patterns in the embryos of fishes, amphibians, echinoderms, and ascidians, as well as the genetic and physical perturbations that alter these patterns. This framework demonstrates that a geometrical system based on length-dependent microtubule forces that probe blastomere shape and yolk gradients, biased by cortical polarity domains, may dictate division patterns and overall embryo morphogenesis. These studies thus unravel the default self-organization rules governing early embryogenesis and how they are altered by deterministic regulatory layers.

Original languageEnglish (US)
Pages (from-to)667-682
Number of pages16
JournalDevelopmental cell
Volume39
Issue number6
DOIs
StatePublished - Dec 19 2016

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Keywords

  • cell division
  • cell shape
  • cleavage patterns
  • embryogenesis
  • microtubule asters
  • modeling

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