Generation of human liver chimeric mice for the study of human hepatotropic pathogens

Markus von Schaewen; Gabriela Hrebikova; Alexander Ploss

doi:10.1007/978-1-4939-3661-8_5

Generation of human liver chimeric mice for the study of human hepatotropic pathogens

Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.

Original language	English (US)
Pages (from-to)	79-101
Number of pages	23
Journal	Methods in Molecular Biology
Volume	1438
DOIs	https://doi.org/10.1007/978-1-4939-3661-8_5
State	Published - May 1 2016

All Science Journal Classification (ASJC) codes

Genetics
Molecular Biology

Keywords

DMPK
Hepatitis B virus
Hepatitis C virus
Hepatitis delta virus
Human liver chimeric mice
Humanized mice
Malaria
Viral hepatitis

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10.1007/978-1-4939-3661-8_5

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abstract = "Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.",

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AU - Ploss, Alexander

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AB - Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.

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KW - Malaria

KW - Viral hepatitis

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Generation of human liver chimeric mice for the study of human hepatotropic pathogens

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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