Generation of human liver chimeric mice for the study of human hepatotropic pathogens

Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.

Original languageEnglish (US)
Pages (from-to)79-101
Number of pages23
JournalMethods in Molecular Biology
Volume1438
DOIs
StatePublished - May 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Keywords

  • DMPK
  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatitis delta virus
  • Human liver chimeric mice
  • Humanized mice
  • Malaria
  • Viral hepatitis

Fingerprint Dive into the research topics of 'Generation of human liver chimeric mice for the study of human hepatotropic pathogens'. Together they form a unique fingerprint.

  • Cite this