General bio-separation superstructure optimization framework

Wenzhao Wu, Kirti Yenkie, Christos T. Maravelias

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent advances in synthetic biology and metabolic engineering have enabled the production of a range of chemicals using engineered microorganisms1,2. However, despite the intriguing potential, the biological production of high-value chemicals is challenging because it is likely to have low titer and substantial amounts of excreted byproducts, and the purity specifications for high-value chemicals, as opposed to fuels, are rather strict, which means that separation costs are likely to represent a large fraction of the total production cost (more than 70% of total cost3). Thus, the efficient synthesis of bio-separation processes becomes a critical task. Although this synthesis problem has been studied for various chemicals in the past, these studies were mostly performed on a case-by-case basis. There has been limited research towards the development of systematic methods for bio-separations, applicable to all chemical targets. Accordingly, the goal of the present work is to develop a general bio-separation superstructure optimization framework, aiming to provide guidance on the preliminary synthesis of separation networks.

Original languageEnglish (US)
Title of host publicationSustainable Engineering Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
PublisherAIChE
Pages446-448
Number of pages3
ISBN (Electronic)9781510834491
StatePublished - 2016
Externally publishedYes
EventSustainable Engineering Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting - San Francisco, United States
Duration: Nov 13 2016Nov 18 2016

Publication series

NameSustainable Engineering Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting

Conference

ConferenceSustainable Engineering Forum 2016 - Core Programming Area at the 2016 AIChE Annual Meeting
CountryUnited States
CitySan Francisco
Period11/13/1611/18/16

All Science Journal Classification (ASJC) codes

  • Renewable Energy, Sustainability and the Environment
  • Chemical Engineering(all)
  • Engineering(all)

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