Gene regulatory networks for development

Michael Levine, Eric H. Davidson

Research output: Contribution to journalReview articlepeer-review

459 Scopus citations

Abstract

The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression. The regulatory inputs and functional outputs of developmental control genes constitute network-like architectures. In this PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the formation of various tissues and organs in nematodes, flies, sea urchins, frogs, and mammals. Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo.

Original languageEnglish (US)
Pages (from-to)4936-4942
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number14
DOIs
StatePublished - Apr 5 2005

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Gene regulatory networks for development'. Together they form a unique fingerprint.

Cite this