Gastrulation in Drosophila: The formation of the ventral furrow and posterior midgut invaginations

Dari Sweeton, Suki Parks, Michael Costa, Eric Wieschaus

Research output: Contribution to journalArticlepeer-review

280 Scopus citations

Abstract

The ventral furrow and posterior midgut invaginations bring mesodermal and endodermal precursor cells into the interior of the Drosophila embryo during gastrulation. Both invaginations proceed through a similar sequence of rapid cell shape changes, which include apical flattening, constriction of the apical diameter, cell elongation and subsequent shortening. Based on the time course of apical constriction in the ventral furrow and posterior midgut, we identify two phases in this process: first, a slow stochastic phase in which some individual cells begin to constrict and, second, a rapid phase in which the remaining unconstricted cells constrict. Mutations in the concertina or folded gastrulation genes appear to block the transition to the second phase in both the ventral furrow and the posterior midgut invaginations.

Original languageEnglish (US)
Pages (from-to)775-789
Number of pages15
JournalDevelopment
Volume112
Issue number3
StatePublished - Jul 1991

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Drosophila
  • Embryonic development
  • Gastrulation

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