GAGA factor: a multifunctional pioneering chromatin protein

Darya Chetverina, Maksim Erokhin, Paul Schedl

Research output: Contribution to journalReview articlepeer-review

Abstract

The Drosophila GAGA factor (GAF) is a multifunctional protein implicated in nucleosome organization and remodeling, activation and repression of gene expression, long distance enhancer–promoter communication, higher order chromosome structure, and mitosis. This broad range of activities poses questions about how a single protein can perform so many seemingly different and unrelated functions. Current studies argue that GAF acts as a “pioneer” factor, generating nucleosome-free regions of chromatin for different classes of regulatory elements. The removal of nucleosomes from regulatory elements in turn enables other factors to bind to these elements and carry out their specialized functions. Consistent with this view, GAF associates with a collection of chromatin remodelers and also interacts with proteins implicated in different regulatory functions. In this review, we summarize the known activities of GAF and the functions of its protein partners.

Original languageEnglish (US)
Pages (from-to)4125-4141
Number of pages17
JournalCellular and Molecular Life Sciences
Volume78
Issue number9
DOIs
StatePublished - May 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Keywords

  • Architectural protein
  • Boundary protein
  • Chromatin silencing
  • GAF
  • GAGA
  • Insulator
  • Pioneer factor
  • Polycomb
  • Promoter
  • Promoter regulation
  • Transcription regulation

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