Functionally Defined White Matter Reveals Segregated Pathways in Human Ventral Temporal Cortex Associated with Category-Specific Processing

Jesse Gomez, Franco Pestilli, Nathan Witthoft, Golijeh Golarai, Alina Liberman, Sonia Poltoratski, Jennifer Yoon, Kalanit Grill-Spector

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

It is unknown if the white-matter properties associated with specific visual networks selectively affect category-specific processing. In a novel protocol we combined measurements of white-matter structure, functional selectivity, and behavior in the same subjects. We find two parallel white-matter pathways along theventral temporal lobe connecting to either face-selectiveor place-selective regions. Diffusion properties of portions of these tracts adjacent to face-and place-selective regions of ventral temporal cortex correlate with behavioral performance for face or place processing, respectively. Strikingly, adults with developmental prosopagnosia (face blindness) express an atypical structure-behavior relationshipnear face-selective cortex, suggesting that white-matter atypicalities in this region may have behavioral consequences. These data suggest that examining the interplay between cortical function, anatomical connectivity, and visual behavior is integral to understanding functional networks and their role in producing visual abilities and deficits.

Original languageEnglish (US)
Pages (from-to)216-227
Number of pages12
JournalNeuron
Volume85
Issue number1
DOIs
StatePublished - Jan 7 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Gomez, J., Pestilli, F., Witthoft, N., Golarai, G., Liberman, A., Poltoratski, S., Yoon, J., & Grill-Spector, K. (2015). Functionally Defined White Matter Reveals Segregated Pathways in Human Ventral Temporal Cortex Associated with Category-Specific Processing. Neuron, 85(1), 216-227. https://doi.org/10.1016/j.neuron.2014.12.027