Functional topographic mapping of the cortical ribbon in human vision with conventional MRI scanners

Walter Schneider, Douglas C. Noll, Jonathan D. Cohen

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

THE human brain has anatomically distinct areas in which processing is laid out in space at the millimetre level with substantial variation across individuals. Activity occurs along a cortical ribbon 1.5-3 mm thick1 in response to specific stimuli2,3. Here we report the first use of cortical ribbon analysis on humans using non-invasive functional magnetic resonance imaging techniques performed with a conventional 1.5 T MRI scanner. Changes in activation were detected using T2*-weighted, gradient echo imaging sequences. Subjects observed partial field, flashing checkerboard patterns (left-right, top-bottom, half rings, and wedges). Stimuli produced magnetic resonance signal changes in the 1-8% range, varying at the millimetre scale, which showed contralateral vertically reflected patterns of activation in the visual cortex. To compare the spatial topographies across subjects, computer algorithms were used to control for the subject-unique folding of cortex, providing a flattened cortical ribbon identifying four topographically distinct areas.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalNature
Volume365
Issue number6442
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • General

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