Functional integration of adult-born neurons

Marie Carlén; Robert M. Cassidy; Hjalmar Brismar; Gregory A. Smith; Lynn W. Enquist; Jonas Frisén

doi:10.1016/S0960-9822(02)00771-6

Functional integration of adult-born neurons

Marie Carlén, Robert M. Cassidy, Hjalmar Brismar, Gregory A. Smith, Lynn W. Enquist, Jonas Frisén

Research output: Contribution to journal › Article › peer-review

254 Scopus citations

Abstract

Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

Original language	English (US)
Pages (from-to)	606-608
Number of pages	3
Journal	Current Biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S0960-9822(02)00771-6
State	Published - Apr 2 2002

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Neuroscience
General Agricultural and Biological Sciences

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10.1016/S0960-9822(02)00771-6

Cite this

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title = "Functional integration of adult-born neurons",

abstract = "Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.",

author = "Marie Carl{\'e}n and Cassidy, {Robert M.} and Hjalmar Brismar and Smith, {Gregory A.} and Enquist, {Lynn W.} and Jonas Fris{\'e}n",

note = "Funding Information: We thank Pasko Rakic, Johan Ericson, Urban Lendahl, and Lennart Phillipson for helpful comments on the manuscript, Rebecca Tirabassi for help with virus construction, and Tony Del Rio for advice on viral immunohistochemistry. This project was supported by the Swedish Foundation for Strategic Research, the Swedish Medical Research Council, Project A.L.S., EU QLG3-2000-01343, the Karolinska Institute, and the Swedish Cancer Foundation.",

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doi = "10.1016/S0960-9822(02)00771-6",

language = "English (US)",

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T1 - Functional integration of adult-born neurons

AU - Carlén, Marie

AU - Cassidy, Robert M.

AU - Brismar, Hjalmar

AU - Smith, Gregory A.

AU - Enquist, Lynn W.

AU - Frisén, Jonas

N1 - Funding Information: We thank Pasko Rakic, Johan Ericson, Urban Lendahl, and Lennart Phillipson for helpful comments on the manuscript, Rebecca Tirabassi for help with virus construction, and Tony Del Rio for advice on viral immunohistochemistry. This project was supported by the Swedish Foundation for Strategic Research, the Swedish Medical Research Council, Project A.L.S., EU QLG3-2000-01343, the Karolinska Institute, and the Swedish Cancer Foundation.

PY - 2002/4/2

Y1 - 2002/4/2

N2 - Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

AB - Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

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Functional integration of adult-born neurons

Abstract

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