Functional integration of adult-born neurons

Marie Carlén, Robert M. Cassidy, Hjalmar Brismar, Gregory A. Smith, Lynn W. Enquist, Jonas Frisén

Research output: Contribution to journalArticle

237 Scopus citations

Abstract

Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalCurrent Biology
Volume12
Issue number7
DOIs
StatePublished - Apr 2 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Carlén, M., Cassidy, R. M., Brismar, H., Smith, G. A., Enquist, L. W., & Frisén, J. (2002). Functional integration of adult-born neurons. Current Biology, 12(7), 606-608. https://doi.org/10.1016/S0960-9822(02)00771-6