Abstract
Metastasis, the spread of cancer from primary tumors to distant vital organs, has devastating consequences. Lack of effective tools to study this complex problem has hindered the development of accurate prognostic methods and effective treatments for metastatic cancer. In the postgenomic era, the application of genomic profiling methods to the analysis of clinical metastasis samples and animal metastasis models has revolutionized the field of metastasis research. This article reviews recent breakthroughs in the functional genomic analysis of metastasis. In addition, its impacts on our understanding of the molecular basis of metastasis and on clinical practice are discussed.
Original language | English (US) |
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Pages (from-to) | 385-395 |
Number of pages | 11 |
Journal | Expert Review of Molecular Diagnostics |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - May 2005 |
All Science Journal Classification (ASJC) codes
- Genetics
- Molecular Medicine
- Molecular Biology
- Pathology and Forensic Medicine
Keywords
- Cancer
- DNA microarray
- Diagnosis
- Expression profiling
- Functional genomics
- Metastasis
- Mouse model
- Prognosis