Functional genomic analysis of cancer metastasis: Biologic insights and clinical implications

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Abstract

Metastasis, the spread of cancer from primary tumors to distant vital organs, has devastating consequences. Lack of effective tools to study this complex problem has hindered the development of accurate prognostic methods and effective treatments for metastatic cancer. In the postgenomic era, the application of genomic profiling methods to the analysis of clinical metastasis samples and animal metastasis models has revolutionized the field of metastasis research. This article reviews recent breakthroughs in the functional genomic analysis of metastasis. In addition, its impacts on our understanding of the molecular basis of metastasis and on clinical practice are discussed.

Original languageEnglish (US)
Pages (from-to)385-395
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume5
Issue number3
DOIs
StatePublished - May 1 2005

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Keywords

  • Cancer
  • DNA microarray
  • Diagnosis
  • Expression profiling
  • Functional genomics
  • Metastasis
  • Mouse model
  • Prognosis

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