Function without form in synthetic polymers mimicking protein hydration

Michael A. Webb

doi:10.1038/s41557-025-01858-0

Function without form in synthetic polymers mimicking protein hydration

Michael A. Webb

Chemical & Biological Engineering

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Hydration frustration — such as burying polar residues or exposing hydrophobic ones — is a hallmark of protein chemistry and critical for biological functions. Now, such frustration can be designed using synthetic copolymers, without the need for defined sequence or structure.

Original language	English (US)
Pages (from-to)	979-981
Number of pages	3
Journal	Nature chemistry
Volume	17
Issue number	7
DOIs	https://doi.org/10.1038/s41557-025-01858-0
State	Published - Jul 2025

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

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10.1038/s41557-025-01858-0

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title = "Function without form in synthetic polymers mimicking protein hydration",

abstract = "Hydration frustration — such as burying polar residues or exposing hydrophobic ones — is a hallmark of protein chemistry and critical for biological functions. Now, such frustration can be designed using synthetic copolymers, without the need for defined sequence or structure.",

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Function without form in synthetic polymers mimicking protein hydration

Abstract

All Science Journal Classification (ASJC) codes

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