Function-based intersubject alignment of human cortical anatomy

Mert R. Sabuncu, Benjamin D. Singer, Bryan Conroy, Ronald E. Bryan, Peter Jeffrey Ramadge, James V. Haxby

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm-viewing static images of objects and faces-and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis.

Original languageEnglish (US)
Pages (from-to)130-140
Number of pages11
JournalCerebral Cortex
Issue number1
StatePublished - Jan 2010

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience


  • Between-subject alignment
  • FMRI
  • Human cortex
  • Neuroimaging


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