FUEL-mLoc: Feature-unified prediction and explanation of multi-localization of cellular proteins in multiple organisms

Shibiao Wan, Man Wai Mak, Sun-Yuan Kung

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Although many web-servers for predicting protein subcellular localization have been developed, they often have the following drawbacks: (i) lack of interpretability or interpreting results with heterogenous information which may confuse users; (ii) ignoring multi-location proteins and (iii) only focusing on specific organism. To tackle these problems, we present an interpretable and efficient web-server, namely FUEL-mLoc, using Feature-Unified prediction and Explanation of multi- Localization of cellular proteins in multiple organisms. Compared to conventional localization predictors, FUEL-mLoc has the following advantages: (i) using unified features (i.e. essential GO terms) to interpret why a prediction is made; (ii) being capable of predicting both single- and multi-location proteins and (iii) being able to handle proteins of multiple organisms, including Eukaryota, Homo sapiens, Viridiplantae, Gram-positive Bacteria, Gram-negative Bacteria and Virus. Experimental results demonstrate that FUEL-mLoc outperforms state-of-the-art subcellular-localization predictors.

Original languageEnglish (US)
Pages (from-to)749-750
Number of pages2
JournalBioinformatics
Volume33
Issue number5
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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