fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology in Drosophila melanogaster

Eric Wieschaus, J. L. Marsh, Walter Gehring

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Females homozygous for a newly isolated mutation induced by ethyl methane sulphonate, fs(1)K10, lay abnormally shaped eggs in which the dorsal appendages of the chorion are enlarged and fused ventrally. The eggs are usually not fertilized and development is never normal beyond the blastoderm stage. The mutant was mapped to the tip of the X-chromosome with a meiotic position of 1-0.5 and a cytological location between 2B17 and 3A3. Using germ line mosaics constructed by transplantation of pole cells, it was shown that the abnormal morphology and the sterility are obtained only when the germ line is homozygous for the mutant.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalWilhelm Roux's Archives of Developmental Biology
Volume184
Issue number1
DOIs
StatePublished - Mar 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Keywords

  • Drosophila
  • Egg shape
  • Pole cell transplantation
  • Sterility

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