Frequency distribution of Wuchereria bancrofti infection in the vector host in relation to human host: evidence for density dependence

P. K. Das, S. Subramanian, A. Manoharan, K. D. Ramaiah, P. Vanamail, B. T. Grenfell, D. A.P. Bundy, E. Michael

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

This paper uses detailed entomological data from Pondicherry to compare the microfilaria distribution in vector with that of human and also to examine the evidence for the operation of density dependence on parasite transmission. Analysis showed that the distribution in vector is similar to that in human. The expected distribution derived from the fit of a zero-truncated negative binomial to the human data, closely reflected the observed microfilaria distribution in the vector. This implies that a relatively large proportion of observed microfilaria negatives in the vector population may be true zeros, as observed in human, arising from the biting on true negatives (as yet uninfected, with unmated female worms or immune) in humans, rather than attributable to the blood sampling process. Further it was found that both the prevalence of infection and the degree of parasite aggregation in the vector population falls significantly with parasite stage, implying the operation of density dependence, perhaps via parasite-induced vector mortality.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalActa Tropica
Volume60
Issue number3
DOIs
StatePublished - Dec 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • veterinary (miscalleneous)
  • Insect Science
  • Infectious Diseases

Keywords

  • Culex quinquefasciatus
  • Frequency distribution
  • Negative binomial
  • Vector
  • Wuchereria bancroft

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