Free-energy landscape of enzyme catalysis

Stephen J. Benkovic, Gordon G. Hammes, Sharon Hammes-Schiffer

Research output: Contribution to journalArticlepeer-review

230 Scopus citations


The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.

Original languageEnglish (US)
Pages (from-to)3317-3321
Number of pages5
Issue number11
StatePublished - Mar 18 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry


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