Free energies, landscapes, and fitness in evolution dynamics

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We will discuss how, on a complex landscape of stress (which corresponds to a free energy landscape), the common bacterium E. coli can evolve very high resistance to an antibiotic in about 10 hours, which is remarkably only at most 20 generations. Furthermore, the resistance has a surprisingly parsimonious genetic prole: Only four single nucleotide polymorphisms (SNPs). How is this possible? How did a bacterium with the presumably low mutation rate μ of only 10-9 SNPs/basepair-replication so quickly nd the magic four.

Original languageEnglish (US)
Title of host publicationQuantitative Biology
Subtitle of host publicationFrom Molecular to Cellular Systems
PublisherCRC Press
Pages1-21
Number of pages21
ISBN (Electronic)9781439827239
ISBN (Print)9781439827222
DOIs
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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