Free energies, landscapes, and fitness in evolution dynamics

Robert Hamilton Austin

doi:10.1201/b12676

Free energies, landscapes, and fitness in evolution dynamics

Robert Hamilton Austin

Physics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We will discuss how, on a complex landscape of stress (which corresponds to a free energy landscape), the common bacterium E. coli can evolve very high resistance to an antibiotic in about 10 hours, which is remarkably only at most 20 generations. Furthermore, the resistance has a surprisingly parsimonious genetic prole: Only four single nucleotide polymorphisms (SNPs). How is this possible? How did a bacterium with the presumably low mutation rate μ of only 10-9 SNPs/basepair-replication so quickly nd the magic four.

Original language	English (US)
Title of host publication	Quantitative Biology
Subtitle of host publication	From Molecular to Cellular Systems
Publisher	CRC Press
Pages	1-21
Number of pages	21
ISBN (Electronic)	9781439827239
ISBN (Print)	9781439827222
DOIs	https://doi.org/10.1201/b12676
State	Published - Jan 1 2012

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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10.1201/b12676

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Free energies, landscapes, and fitness in evolution dynamics

Abstract

All Science Journal Classification (ASJC) codes

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