Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells

W. W. Colby; T. Shenk

doi:10.1073/pnas.79.17.5189

Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells

W. W. Colby, T. Shenk

Molecular Biology

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Segments of the simian virus 40 (SV40) genome that encode only fragments of large tumor antigen can facilitate immortalization of secondary rat embryo cells. The phenotypes of the immortalized cells range from nearly 'normal' to fully transformed. All of the cell lines contain SV40 sequences and express unstable NH₂-terminal fragments of large tumor antigen. SV40 small tumor antigen does not appear to be essential for either immortalization or transformation.

Original language	English (US)
Pages (from-to)	5189-5193
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	17 I
DOIs	https://doi.org/10.1073/pnas.79.17.5189
State	Published - 1982

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1073/pnas.79.17.5189

Cite this

@article{260cf7cec97a4d01a86e20ba840f63ee,

title = "Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells",

abstract = "Segments of the simian virus 40 (SV40) genome that encode only fragments of large tumor antigen can facilitate immortalization of secondary rat embryo cells. The phenotypes of the immortalized cells range from nearly 'normal' to fully transformed. All of the cell lines contain SV40 sequences and express unstable NH2-terminal fragments of large tumor antigen. SV40 small tumor antigen does not appear to be essential for either immortalization or transformation.",

author = "Colby, {W. W.} and T. Shenk",

year = "1982",

doi = "10.1073/pnas.79.17.5189",

language = "English (US)",

volume = "79",

pages = "5189--5193",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "17 I",

}

TY - JOUR

T1 - Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells

AU - Colby, W. W.

AU - Shenk, T.

PY - 1982

Y1 - 1982

N2 - Segments of the simian virus 40 (SV40) genome that encode only fragments of large tumor antigen can facilitate immortalization of secondary rat embryo cells. The phenotypes of the immortalized cells range from nearly 'normal' to fully transformed. All of the cell lines contain SV40 sequences and express unstable NH2-terminal fragments of large tumor antigen. SV40 small tumor antigen does not appear to be essential for either immortalization or transformation.

AB - Segments of the simian virus 40 (SV40) genome that encode only fragments of large tumor antigen can facilitate immortalization of secondary rat embryo cells. The phenotypes of the immortalized cells range from nearly 'normal' to fully transformed. All of the cell lines contain SV40 sequences and express unstable NH2-terminal fragments of large tumor antigen. SV40 small tumor antigen does not appear to be essential for either immortalization or transformation.

UR - http://www.scopus.com/inward/record.url?scp=0020288479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020288479&partnerID=8YFLogxK

U2 - 10.1073/pnas.79.17.5189

DO - 10.1073/pnas.79.17.5189

M3 - Article

C2 - 6291029

AN - SCOPUS:0020288479

SN - 0027-8424

VL - 79

SP - 5189

EP - 5193

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 17 I

ER -

Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this