Abstract
Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.
Original language | English (US) |
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Pages (from-to) | 5480-5484 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 42 |
Issue number | 44 |
DOIs | |
State | Published - Nov 17 2003 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- Activity-based profiling
- Hydrolases
- Inhibitors
- Natural products
- Proteomics