(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Gregory C. Adam; Christopher D. Vanderwal; Erik J. Sorensen; Benjamin F. Cravatt

doi:10.1002/anie.200352576

(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Gregory C. Adam, Christopher D. Vanderwal, Erik J. Sorensen, Benjamin F. Cravatt

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.

Original language	English (US)
Pages (from-to)	5480-5484
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	44
DOIs	https://doi.org/10.1002/anie.200352576
State	Published - Nov 17 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)
Catalysis

Keywords

Activity-based profiling
Hydrolases
Inhibitors
Natural products
Proteomics

Access to Document

10.1002/anie.200352576

Cite this

@article{2295f4e2aecc4b508d2fa2a6b4695d68,

title = "(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1",

abstract = "Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.",

keywords = "Activity-based profiling, Hydrolases, Inhibitors, Natural products, Proteomics",

author = "Adam, {Gregory C.} and Vanderwal, {Christopher D.} and Sorensen, {Erik J.} and Cravatt, {Benjamin F.}",

year = "2003",

month = nov,

day = "17",

doi = "10.1002/anie.200352576",

language = "English (US)",

volume = "42",

pages = "5480--5484",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "44",

}

TY - JOUR

T1 - (-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

AU - Adam, Gregory C.

AU - Vanderwal, Christopher D.

AU - Sorensen, Erik J.

AU - Cravatt, Benjamin F.

PY - 2003/11/17

Y1 - 2003/11/17

N2 - Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.

AB - Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.

KW - Activity-based profiling

KW - Hydrolases

KW - Inhibitors

KW - Natural products

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=0344413531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344413531&partnerID=8YFLogxK

U2 - 10.1002/anie.200352576

DO - 10.1002/anie.200352576

M3 - Article

C2 - 14618582

AN - SCOPUS:0344413531

SN - 1433-7851

VL - 42

SP - 5480

EP - 5484

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

ER -

(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this