(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Gregory C. Adam; Christopher D. Vanderwal; Erik J. Sorensen; Benjamin F. Cravatt

doi:10.1002/anie.200352576

(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Gregory C. Adam, Christopher D. Vanderwal, Erik J. Sorensen, Benjamin F. Cravatt

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.

Original language	English (US)
Pages (from-to)	5480-5484
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	44
DOIs	https://doi.org/10.1002/anie.200352576
State	Published - Nov 17 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

Keywords

Activity-based profiling
Hydrolases
Inhibitors
Natural products
Proteomics

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10.1002/anie.200352576

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abstract = "Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.",

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AU - Vanderwal, Christopher D.

AU - Sorensen, Erik J.

AU - Cravatt, Benjamin F.

PY - 2003/11/17

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AB - Activity-based profiling and reporter-group-tagged compounds were used to identify carboxylesterase-1 (CE-1) as a specific target of the natural product (-)-FR182877 (see scheme). Now that a target is known, specific modification of the lactone natural product may lead to even more effective inhibitors of CE-1.

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KW - Hydrolases

KW - Inhibitors

KW - Natural products

KW - Proteomics

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(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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