Flash NanoPrecipitation of Organic Actives and Block Copolymers using a Confined Impinging Jets Mixer

Brian K. Johnson, Robert K. Prud'homme

Research output: Contribution to journalArticle

276 Scopus citations

Abstract

A new technology to form nanoparticles of hydrophobic organic actives at high concentration and yield, as well as methods to characterize the process, are presented. In Flash NanoPrecipitation, an organic active and an amphiphilic diblock copolymer are molecularly dissolved in an organic phase and mixed rapidly with a miscible anti-solvent to afford precipitation of the active with a tunable, narrow submicron particle size distribution from 1 μm to 80 nm. The enabling components are a novel 'analytical' (quantified mixing time) confined impinging jets (CIJ) mixer for millisecond stream homogenization and amphiphilic diblock copolymers which alter the organic nucleation and growth, provide steric stabilization for the particles, and offer a functional surface for the particle. Applications in enhanced pharmaceutical delivery, dye preparation, and pesticide formulation are specifically targeted.

Original languageEnglish (US)
Pages (from-to)1021-1024
Number of pages4
JournalAustralian Journal of Chemistry
Volume56
Issue number10
DOIs
StatePublished - Oct 17 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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