TY - JOUR
T1 - Flash NanoPrecipitation of Organic Actives and Block Copolymers using a Confined Impinging Jets Mixer
AU - Johnson, Brian K.
AU - Prud'homme, Robert K.
PY - 2003
Y1 - 2003
N2 - A new technology to form nanoparticles of hydrophobic organic actives at high concentration and yield, as well as methods to characterize the process, are presented. In Flash NanoPrecipitation, an organic active and an amphiphilic diblock copolymer are molecularly dissolved in an organic phase and mixed rapidly with a miscible anti-solvent to afford precipitation of the active with a tunable, narrow submicron particle size distribution from 1 μm to 80 nm. The enabling components are a novel 'analytical' (quantified mixing time) confined impinging jets (CIJ) mixer for millisecond stream homogenization and amphiphilic diblock copolymers which alter the organic nucleation and growth, provide steric stabilization for the particles, and offer a functional surface for the particle. Applications in enhanced pharmaceutical delivery, dye preparation, and pesticide formulation are specifically targeted.
AB - A new technology to form nanoparticles of hydrophobic organic actives at high concentration and yield, as well as methods to characterize the process, are presented. In Flash NanoPrecipitation, an organic active and an amphiphilic diblock copolymer are molecularly dissolved in an organic phase and mixed rapidly with a miscible anti-solvent to afford precipitation of the active with a tunable, narrow submicron particle size distribution from 1 μm to 80 nm. The enabling components are a novel 'analytical' (quantified mixing time) confined impinging jets (CIJ) mixer for millisecond stream homogenization and amphiphilic diblock copolymers which alter the organic nucleation and growth, provide steric stabilization for the particles, and offer a functional surface for the particle. Applications in enhanced pharmaceutical delivery, dye preparation, and pesticide formulation are specifically targeted.
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U2 - 10.1071/CH03115
DO - 10.1071/CH03115
M3 - Article
AN - SCOPUS:0141927375
SN - 0004-9425
VL - 56
SP - 1021
EP - 1024
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 10
ER -