Flash Nano-precipitation and -complexation to Produce Polymer Colloids

Victoria E. Lee, Douglas M. Scott, Robert K. Prud’Homme, Rodney D. Priestley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In this chapter, we have reviewed FNP and FNC as two promising processes with which to prepare polymer colloids. While rapid mixing and subsequent solvent exchange during FNP result in collapse and aggregation of polymer globules to form monodisperse polymer colloids, phase separation between chemically distinct polymers can further result in the formation of colloids with complex internal structures, including those with Janus, core–shell, and hierarchically-structured morphologies. Alternatively, FNC relies on the complexation of two oppositely-charged species upon mixing to create polymer colloids without the need for organic solvents and has been shown to effectively encapsulate a variety of payloads. We have reviewed the various equipment configurations that can be used to perform both FNP and FNC and emphasize that these processes can be run in a continuous manner at room temperature, making them economical options and requiring relatively few alterations to scale up the production of polymer colloids.

Original languageEnglish (US)
Title of host publicationPolymer Colloids
Subtitle of host publicationFormation, Characterization and Applications
EditorsRodney D. Priestley, Robert K. Prud'homme
PublisherRoyal Society of Chemistry
Number of pages39
ISBN (Electronic)9781788014175
StatePublished - Jan 1 2020

Publication series

NameRSC Soft Matter
ISSN (Print)2048-7681
ISSN (Electronic)2048-769X

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • General Chemistry
  • General Chemical Engineering


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