Five challenges in evolution and infectious diseases

C. J.E. Metcalf; R. B. Birger; S. Funk; R. D. Kouyos; J. O. Lloyd-Smith; V. A.A. Jansen

doi:10.1016/j.epidem.2014.12.003

Five challenges in evolution and infectious diseases

C. J.E. Metcalf, R. B. Birger, S. Funk, R. D. Kouyos, J. O. Lloyd-Smith, V. A.A. Jansen

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Epidemics
Volume	10
DOIs	https://doi.org/10.1016/j.epidem.2014.12.003
State	Published - Mar 1 2015

All Science Journal Classification (ASJC) codes

Public Health, Environmental and Occupational Health
Infectious Diseases
Epidemiology
Virology
Parasitology
Microbiology

Keywords

Coinfection
Diversity
Fitness
Genetic systems
R0

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10.1016/j.epidem.2014.12.003

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AU - Funk, S.

AU - Kouyos, R. D.

AU - Lloyd-Smith, J. O.

AU - Jansen, V. A.A.

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AB - Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data.

KW - Coinfection

KW - Diversity

KW - Fitness

KW - Genetic systems

KW - R0

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Five challenges in evolution and infectious diseases

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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