Five challenges in evolution and infectious diseases

C. J.E. Metcalf, R. B. Birger, S. Funk, R. D. Kouyos, J. O. Lloyd-Smith, V. A.A. Jansen

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Epidemiology
  • Virology
  • Parasitology
  • Microbiology


  • Coinfection
  • Diversity
  • Fitness
  • Genetic systems
  • R0


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