Fibronectin fibrillogenesis, a cell-mediated matrix assembly process

Research output: Contribution to journalReview article

526 Scopus citations

Abstract

The extracellular matrix provides a framework for cell adhesion, supports cell movement, and serves to compartmentalize tissues into functional units. Fibronectin is a core component of many extracellular matrices where it regulates a variety of cell activities through direct interactions with cell surface integrin receptors. Fibronectin is synthesized by many adherent cells which then assemble it into a fibrillar network. The assembly process is integrin-dependent and fibronectin-integrin interactions initiate a step-wise process involving conformational activation of fibronectin outside and organization of the actin cytoskeleton inside. During assembly, fibronectin undergoes conformational changes that expose fibronectin-binding sites and promote intermolecular interactions needed for fibril formation. In this review, the main steps of fibronectin assembly are described and recent studies on fibronectin conformational changes are discussed.

Original languageEnglish (US)
Pages (from-to)389-399
Number of pages11
JournalMatrix Biology
Volume24
Issue number6
DOIs
StatePublished - Sep 2005

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Keywords

  • Conformational changes
  • Fibronectin
  • Integrin
  • Matrix assembly

Fingerprint Dive into the research topics of 'Fibronectin fibrillogenesis, a cell-mediated matrix assembly process'. Together they form a unique fingerprint.

  • Cite this