TY - JOUR
T1 - Fibronectin fibrillogenesis, a cell-mediated matrix assembly process
AU - Mao, Yong
AU - Schwarzbauer, Jean E.
PY - 2005/9
Y1 - 2005/9
N2 - The extracellular matrix provides a framework for cell adhesion, supports cell movement, and serves to compartmentalize tissues into functional units. Fibronectin is a core component of many extracellular matrices where it regulates a variety of cell activities through direct interactions with cell surface integrin receptors. Fibronectin is synthesized by many adherent cells which then assemble it into a fibrillar network. The assembly process is integrin-dependent and fibronectin-integrin interactions initiate a step-wise process involving conformational activation of fibronectin outside and organization of the actin cytoskeleton inside. During assembly, fibronectin undergoes conformational changes that expose fibronectin-binding sites and promote intermolecular interactions needed for fibril formation. In this review, the main steps of fibronectin assembly are described and recent studies on fibronectin conformational changes are discussed.
AB - The extracellular matrix provides a framework for cell adhesion, supports cell movement, and serves to compartmentalize tissues into functional units. Fibronectin is a core component of many extracellular matrices where it regulates a variety of cell activities through direct interactions with cell surface integrin receptors. Fibronectin is synthesized by many adherent cells which then assemble it into a fibrillar network. The assembly process is integrin-dependent and fibronectin-integrin interactions initiate a step-wise process involving conformational activation of fibronectin outside and organization of the actin cytoskeleton inside. During assembly, fibronectin undergoes conformational changes that expose fibronectin-binding sites and promote intermolecular interactions needed for fibril formation. In this review, the main steps of fibronectin assembly are described and recent studies on fibronectin conformational changes are discussed.
KW - Conformational changes
KW - Fibronectin
KW - Integrin
KW - Matrix assembly
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U2 - 10.1016/j.matbio.2005.06.008
DO - 10.1016/j.matbio.2005.06.008
M3 - Review article
C2 - 16061370
AN - SCOPUS:28844459379
VL - 24
SP - 389
EP - 399
JO - Collagen and Related Research
JF - Collagen and Related Research
SN - 0945-053X
IS - 6
ER -