Feeding the germline

Cheng Shi, Coleen T. Murphy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307–320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)- supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.

Original languageEnglish (US)
Pages (from-to)249-250
Number of pages2
JournalGenes and Development
Volume30
Issue number3
DOIs
StatePublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Keywords

  • CRP
  • CytR
  • Gld-1
  • HT115
  • Nucleotide salvage pathway
  • Nutrient sensing

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