Abstract
Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307–320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)- supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
Original language | English (US) |
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Pages (from-to) | 249-250 |
Number of pages | 2 |
Journal | Genes and Development |
Volume | 30 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2016 |
All Science Journal Classification (ASJC) codes
- Genetics
- Developmental Biology
Keywords
- CRP
- CytR
- Gld-1
- HT115
- Nucleotide salvage pathway
- Nutrient sensing