Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307–320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)- supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
All Science Journal Classification (ASJC) codes
- Developmental Biology
- Nucleotide salvage pathway
- Nutrient sensing