@inproceedings{d4088a535f6d4427a8cf1782b5eeda0d,
title = "Fast wavelet-based single-particle reconstruction in Cryo-EM",
abstract = "This paper presents a novel algorithm for the 3D tomographic inversion problem that arises in single-particle electron cryomicroscopy (Cryo-EM). It is based on two key components: 1) a variational formulation that promotes sparsity in the wavelet domain and 2) the Toeplitz structure of the combined projection/back-projection operator. The first idea has proven to be very effective for the recovery of piecewise-smooth signals, which is confirmed by our numerical experiments. The second idea allows for a computationally efficient implementation of the reconstruction procedure, using only one circulant convolution per iteration.",
keywords = "3D, Inverse problem, Toeplitz structure, electron cryo-microscopy (Cryo-EM), non-uniform FFT, one-norm regularization, projection-slice theorem, single particle reconstruction, sparsity, wavelets",
author = "C{\'e}dric Vonesch and Lanhui Wang and Yoel Shkolnisky and Amit Singer",
year = "2011",
doi = "10.1109/ISBI.2011.5872791",
language = "English (US)",
isbn = "9781424441280",
series = "Proceedings - International Symposium on Biomedical Imaging",
pages = "1950--1953",
booktitle = "2011 8th IEEE International Symposium on Biomedical Imaging",
note = "2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 ; Conference date: 30-03-2011 Through 02-04-2011",
}