Abstract
The trigeminal motor nucleus (MoV) contains the somata of the motoneurons that control jaw position and jaw movements. This nucleus is of neurochemical interest because it recieves a dense serotonergic input. We examined the effects of application oof serotonin or fluoxetine, a serotonin reuptake blocker, into this nucleus on the spontaneous or reflex (jaw-closure) electrical activity of the masseter muscle in behaving cats. Serotonin produced a clearcut enhancement of both spontaneous and reflex activities. This action was attenuated by previous systemic injection of the serotonin receptor antagonist methysergide. The effect was mimicked to a certain extent by fluoxetine. These data provide evidence that the serotonergic input to MoV exerts a general facilitatory influence on masseter motoneurons activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-204 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 550 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 7 1991 |
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Molecular Biology
- General Neuroscience
- Developmental Biology
Keywords
- Jaw-closure reflex
- Masseter electromyogram
- Masseteric reflex
- Mesencephalic trigeminal nucleus
- Serotonin
- Trigeminal motor nucleus
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