Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective

Andrew J. Loder; Benjamin M. Zeldes; Jonathan M. Conway; James A. Counts; Christopher T. Straub; Piyum A. Khatibi; Laura L. Lee; Nicholas P. Vitko; Matthew W. Keller; Amanda M. Rhaesa; Gabe M. Rubinstein; Israel M. Scott; Gina L. Lipscomb; Michael W.W. Adams; Robert M. Kelly

doi:10.1002/9783527807796.ch14

Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective

Andrew J. Loder, Benjamin M. Zeldes, Jonathan M. Conway, James A. Counts, Christopher T. Straub, Piyum A. Khatibi, Laura L. Lee, Nicholas P. Vitko, Matthew W. Keller, Amanda M. Rhaesa, Gabe M. Rubinstein, Israel M. Scott, Gina L. Lipscomb, Michael W.W. Adams, Robert M. Kelly

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

Recent advances in molecular genetic tools for extreme thermophiles have made it possible to begin using them as platforms for metabolic engineering for the production of fuels and chemicals. To the point, this chapter focuses on the current state of tools and applications of extreme thermophiles for metabolic engineering. Discussed here are the advantages and drawbacks of using extreme thermophiles as industrials hosts, as well as considerations for selecting an appropriate host from this group of microorganisms. The genetic strategies and tools available for several extreme thermophiles are discussed, including the variety of genetic elements that could be considered. Finally, applications of metabolic engineering with extreme thermophiles are presented along with perspectives on future developments in this emerging technology.

Original language	English (US)
Title of host publication	Industrial Biotechnology
Subtitle of host publication	Microorganisms: Volume 1, 2
Publisher	wiley
Pages	505-580
Number of pages	76
Volume	1-2
ISBN (Electronic)	9783527807796
ISBN (Print)	9783527341795
DOIs	https://doi.org/10.1002/9783527807796.ch14
State	Published - Jan 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

Keywords

Biobased chemicals/fuels
Extreme thermophiles
Metabolic engineering

Access to Document

10.1002/9783527807796.ch14

Cite this

Loder, A. J., Zeldes, B. M., Conway, J. M., Counts, J. A., Straub, C. T., Khatibi, P. A., Lee, L. L., Vitko, N. P., Keller, M. W., Rhaesa, A. M., Rubinstein, G. M., Scott, I. M., Lipscomb, G. L., Adams, M. W. W., & Kelly, R. M. (2016). Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective. In Industrial Biotechnology: Microorganisms: Volume 1, 2 (Vol. 1-2, pp. 505-580). wiley. https://doi.org/10.1002/9783527807796.ch14

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abstract = "Recent advances in molecular genetic tools for extreme thermophiles have made it possible to begin using them as platforms for metabolic engineering for the production of fuels and chemicals. To the point, this chapter focuses on the current state of tools and applications of extreme thermophiles for metabolic engineering. Discussed here are the advantages and drawbacks of using extreme thermophiles as industrials hosts, as well as considerations for selecting an appropriate host from this group of microorganisms. The genetic strategies and tools available for several extreme thermophiles are discussed, including the variety of genetic elements that could be considered. Finally, applications of metabolic engineering with extreme thermophiles are presented along with perspectives on future developments in this emerging technology.",

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Loder, AJ, Zeldes, BM, Conway, JM, Counts, JA, Straub, CT, Khatibi, PA, Lee, LL, Vitko, NP, Keller, MW, Rhaesa, AM, Rubinstein, GM, Scott, IM, Lipscomb, GL, Adams, MWW & Kelly, RM 2016, Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective. in Industrial Biotechnology: Microorganisms: Volume 1, 2. vol. 1-2, wiley, pp. 505-580. https://doi.org/10.1002/9783527807796.ch14

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AU - Loder, Andrew J.

AU - Zeldes, Benjamin M.

AU - Conway, Jonathan M.

AU - Counts, James A.

AU - Straub, Christopher T.

AU - Khatibi, Piyum A.

AU - Lee, Laura L.

AU - Vitko, Nicholas P.

AU - Keller, Matthew W.

AU - Rhaesa, Amanda M.

AU - Rubinstein, Gabe M.

AU - Scott, Israel M.

AU - Lipscomb, Gina L.

AU - Adams, Michael W.W.

AU - Kelly, Robert M.

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Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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