Extrachromosomal elements cause a reduced division potential in nib 1 strains of Saccharomyces cerevisiae.

R. Sweeney, Virginia Araxie Zakian

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The nib 1 allele of yeast confers a sensitivity to an endogenous plasmid, 2 mu DNA, in that nib 1 strains bearing 2 mu DNA (cir+) exhibit a reduction in division potential. In the present study, the reduction in division potential characteristic of nib 1 cir+ strains is shown to be dependent on the simultaneous presence of both the A and the D open reading frames of 2 mu DNA as well as on the presence of an unidentified extrachromosomal element other than 2 mu DNA. Furthermore, in nib 1 strains, an uncharacterized extrachromosomal element can cause a less severe reduction of division potential in the absence of intact 2 mu DNA. Thus, the nib 1 allele may confer a generalized sensitivity to extrachromosomal elements.

Original languageEnglish (US)
Pages (from-to)749-757
Number of pages9
JournalGenetics
Volume122
Issue number4
StatePublished - Aug 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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