Extending tests of hardy-weinberg equilibrium to structured populations

Research output: Contribution to journalArticle

Abstract

Testing for Hardy-Weinberg equilibrium (HWE) is an important component in almost all analyses of population genetic data. Genetic markers that violate HWE are often treated as special cases; for example, they may be flagged as possible genotyping errors, or they may be investigated more closely for evolutionary signatures of interest. The presence of population structure is one reason why genetic markers may fail a test of HWE. This is problematic because almost all natural populations studied in the modern setting show some degree of structure. Therefore, it is important to be able to detect deviations from HWE for reasons other than structure. To this end, we extend statistical tests of HWE to allow for population structure, which we call a test of "structural HWE." Additionally, our new test allows one to automatically choose tuning parameters and identify accurate models of structure. We demonstrate our approach on several important studies, provide theoretical justification for the test, and present empirical evidence for its utility. We anticipate the proposed test will be useful in a broad range of analyses of genome-wide population genetic data.

Original languageEnglish (US)
Pages (from-to)759-770
Number of pages12
JournalGenetics
Volume213
Issue number3
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Genetics

Keywords

  • Admixed
  • Admixture
  • Chi-square test
  • HWE
  • Population genetics
  • Quality control
  • Random mating
  • Significance test

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