Exploring and exploiting proteome organization during viral infection

Pierre M.Jean Beltran; Katelyn C. Cook; Ileana M. Cristea

doi:10.1128/JVI.00268-17

Exploring and exploiting proteome organization during viral infection

Pierre M.Jean Beltran, Katelyn C. Cook, Ileana M. Cristea

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.

Original language	English (US)
Article number	e00268-17
Journal	Journal of virology
Volume	91
Issue number	18
DOIs	https://doi.org/10.1128/JVI.00268-17
State	Published - Sep 1 2017

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

Keywords

Mass spectrometry
Microscopy
Organelle
Proteomics
Systems biology
Virus-host interactions

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10.1128/JVI.00268-17

Cite this

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title = "Exploring and exploiting proteome organization during viral infection",

abstract = "Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.",

keywords = "Mass spectrometry, Microscopy, Organelle, Proteomics, Systems biology, Virus-host interactions",

author = "Beltran, {Pierre M.Jean} and Cook, {Katelyn C.} and Cristea, {Ileana M.}",

note = "Funding Information: Many scientists have contributed to organelle studies, and we apologize for not being able to credit all of these important studies. We are grateful for funding from the NIH (R01 GM114141 and R01 HL127640 to I.M.C.), a Mallinckrodt Scholar Award, and a Dodds Fellowship to P.M.J.B. There is no conflict of interest regarding the publication of this article. Publisher Copyright: {\textcopyright} 2017 American Society for Microbiology.",

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doi = "10.1128/JVI.00268-17",

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AU - Cook, Katelyn C.

AU - Cristea, Ileana M.

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N2 - Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.

AB - Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.

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KW - Microscopy

KW - Organelle

KW - Proteomics

KW - Systems biology

KW - Virus-host interactions

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Exploring and exploiting proteome organization during viral infection

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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