Boronic acids, esters and borinic anhydrides are partners in Suzuki-Miyaura cross-coupling reactions with a variety of β-chlorovinamidinium salts to give the desired β-arylvinamidinium salts in up to 88% yield. Reduction is a competing reaction pathway. DFT calculations on the intermediate palladium complex reveal that the Pd-C interaction is predominantly of σ-symmetry and the metal based LUMO is mainly dz2 in character.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry