Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex

Yuji K. Takahashi, Matthew R. Roesch, Robert C. Wilson, Kathy Toreson, Patricio O'Donnell, Yael Niv, Geoffrey Schoenbaum

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

The orbitofrontal cortex has been hypothesized to carry information regarding the value of expected rewards. Such information is essential for associative learning, which relies on comparisons between expected and obtained reward for generating instructive error signals. These error signals are thought to be conveyed by dopamine neurons. To test whether orbitofrontal cortex contributes to these error signals, we recorded from dopamine neurons in orbitofrontal-lesioned rats performing a reward learning task. Lesions caused marked changes in dopaminergic error signaling. However, the effect of lesions was not consistent with a simple loss of information regarding expected value. Instead, without orbitofrontal input, dopaminergic error signals failed to reflect internal information about the impending response that distinguished externally similar states leading to differently valued future rewards. These results are consistent with current conceptualizations of orbitofrontal cortex as supporting model-based behavior and suggest an unexpected role for this information in dopaminergic error signaling.

Original languageEnglish (US)
Pages (from-to)1590-1597
Number of pages8
JournalNature neuroscience
Volume14
Issue number12
DOIs
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Takahashi, Y. K., Roesch, M. R., Wilson, R. C., Toreson, K., O'Donnell, P., Niv, Y., & Schoenbaum, G. (2011). Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex. Nature neuroscience, 14(12), 1590-1597. https://doi.org/10.1038/nn.2957