Expanding chemistry through in vitro and in vivo biocatalysis

Elijah N. Kissman, Max B. Sosa, Douglas C. Millar, Edward J. Koleski, Kershanthen Thevasundaram, Michelle C.Y. Chang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes and cells as potential biocatalysts for chemical processes. The properties of protein and cell biocatalysts—high selectivity, the ability to control reaction sequence and operation in environmentally benign conditions—offer approaches to produce molecules at high efficiency while lowering the cost and environmental impact of industrial chemistry. Furthermore, biocatalysis offers the opportunity to generate chemical structures and functions that may be inaccessible to chemical synthesis. Here we consider developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

Original languageEnglish (US)
Pages (from-to)37-48
Number of pages12
JournalNature
Volume631
Issue number8019
DOIs
StatePublished - Jul 4 2024

All Science Journal Classification (ASJC) codes

  • General

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