Excited-state lifetimes of far-infrared collective modes in proteins

A. Xie, L. Van Der Meer, R. H. Austin

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Vibrational excitations of low frequency collective modes are essential for functionally important conformational transitions in proteins. Here we report the first direct measurement on the lifetime of vibrational excitations of the collective modes at 87 pm (115 cm-1) in bacteriorhodopsin, a transmembrane protein. The data show that these modes have extremely long lifetime of vibrational excitations, over 500 picoseconds, accommodating 1500 vibrations. We suggest that there is a connection between this relatively slow anharmonic relaxation rate of approximately 10 g sec-1 and the similar observed rate of conformational transitions in proteins, which require require multi-level vibrational excitations and energy exchanges with other vibrational modes and collisional motions of solvent molecules.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalJournal of Biological Physics
Volume28
Issue number2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • Molecular Biology
  • Cell Biology

Keywords

  • Bacteriorhodopsin
  • Collective modes
  • Proteins

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