TY - JOUR
T1 - Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
AU - Vernot, Benjamin
AU - Tucci, Serena
AU - Kelso, Janet
AU - Schraiber, Joshua G.
AU - Wolf, Aaron B.
AU - Gittelman, Rachel M.
AU - Dannemann, Michael
AU - Grote, Steffi
AU - McCoy, Rajiv C.
AU - Norton, Heather
AU - Scheinfeldt, Laura B.
AU - Merriwether, David A.
AU - Koki, George
AU - Friedlaender, Jonathan S.
AU - Wakefield, Jon
AU - Pääbo, Svante
AU - Akey, Joshua M.
N1 - Funding Information:
We thank members of the Akey and Pääbo laboratories for helpful feedback related to this work, F. Friedlaender for help in data management, J. Lorenz and J. Madeoy for DNA extractions and purifications, L. Jáuregui for help in figure preparation, and the participants in this study. Whole-genome sequence data have been deposited into the Database of Genotypes and Phenotypes (dbGAP) with the accession number phs001085.v1.p1. This work was supported by an NIH grant (5R01GM110068) to J.M.A., an NSF fellowship (DBI-1402120) to J.G.S., and grants from the Deutsche Forschungsgemeinschaft (SFB1052, project A02) to J.K. and from the Presidential Fund of the Max Planck Society to S.P. Sample collection was supported in part by NSF grants 9601020 and 0413449 to D.A.M. J.M.A. is a paid consultant of Glenview Capital.
PY - 2016/4/8
Y1 - 2016/4/8
N2 - Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression.
AB - Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression.
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U2 - 10.1126/science.aad9416
DO - 10.1126/science.aad9416
M3 - Article
C2 - 26989198
AN - SCOPUS:84961392375
SN - 0036-8075
VL - 352
SP - 235
EP - 239
JO - Science
JF - Science
IS - 6282
ER -